Napoli Vs Pisa Preview, Prediction, Team News, Betting Tips And Odds

Ahead of Monday’s MD4 Serie A clash, FootItalia has the Napoli vs Pisa preview, prediction, betting tips, odds and more. 

Napoli Vs Pisa Preview

Napoli return to domestic action on Monday having lost their 100% winning start to the season at Man City last week. Antonio Conte’s side went down 2-0 to the English Premier League side at the Etihad in their UCL opener.

Although captain Giovanni Di Lorenzo was sent off early on in Manchester, the Azzurri defended resolutely. However, goals from Erling Haaland and Jeremy Doku broke their resistance.

Nonetheless, the Serie A champions have won three out of three in Italy’s elite soccer division this year. Kevin De Bruyne – who was subbed owing to the dismissal against City – scored the opener last time out against Fiorentina.

Fellow newbies Rasmus Hojlund and Sam Beukema also netted in the 3-1 win at the Artemio Franchi. Confidence is certainly still high going into the game at the Maradona Stadium on September 22.

As for Pisa, the newly-promoted side has just a single point to their name so far this campaign. That came on MD1 at Atalanta. They have since slipped to 1-0 defeats to Roma and Udinese on home soil.

Today is their first visit to Naples in league action since 1990. Diego Maradona was on the scoresheet in what was an eventual 2-1 defeat for the Nerazzurri.

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🏟️ Stadio Diego Armando Maradona
🕘 20:45 CEST

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— Official SSC Napoli (@sscnapoli) September 22, 2025

Napoli Vs Pisa Odds And Match Info

• ⚽️ Serie A, MD4
• 🏟️ Maradona Stadium, Naples
• ⏱️ Monday, 22 September: 2:45pm (ET)/11:45am (PT)/8:45pm (CET)
• 🎲 Match Odds: Napoli -286 | Draw +425 | Pisa +1000

Napoli Vs Pisa Team News And Predicted Lineups

With Napoli striker Romelu Lukaku ruled out injured until December, loanee Rasmus Hojlund or Lorenzo Lucca will get the nod to start in attack.

The position may well fall to the former after he netted on MD3 against Fiorentina. Elsewhere, head coach Antonio Conte will need to make a decision on goalkeeper Alex Meret.

A late call will be decided on his fitness with Vanja Milinkovic-Savic on standby to fill the void once again. The Serbian has played well so far this season since making his summer switch from Torino.

Meanwhile, Pisa will be desperate to at least get on the scoreesheet in Naples. Their solitary strike this season in all competitions was actually an own goal by Atalanta.

Therefore, boss Alberto Gilardino will maybe opt for M’Bala Nzola to start in attack ahead of Henrik Meister or Stefano Moreo. The latter is set to start just behind Nzola.

Napoli predicted lineup: Meret; Di Lorenzo, Beukema, Jesus, Spinazzola; Lobotka; Politano, Anguissa, De Bruyne, McTominay; Lucca

Pisa predicted lineup: Semper; Canestrelli, Caracciolo, Bonfanti; Toure, Aebischer, Akinsamiro, Angori; Moreo, Tramoni; Nzola

Napoli Vs Pisa Prediction

On paper, it should be a straightforward win for the champions and it’s hard to see past that outcome on Monday. Despite their UCL setback, Napoli have looked very sharp so far in 2025-26.

With six goals scored and just one conceded, Antonio Conte’s side will be very confident of cruising past their struggling opponents at the Maradona Stadium.

Prediction: Napoli 4-0 Pisa

Napoli Vs Pisa Betting Tips

🔎 Napoli vs Pisa betting tip 1: Kevin De Bruyne to score first at +750

The Belgian baller has made an excellent start to his Napoli career and having scored the opener last week, there’s plenty of value at +750 for KDB to do so again on Monday.

🔎 Napoli vs Pisa betting tip 2: Over 3.5 goals at +240

Napoli appears to be getting into their stride in front of goal and we fancy them to punish struggling Pisa at the Maradona Stadium.